The main focus of the lab is to study the development and function the retina. We utilize all the genetic and developmental advantages of zebrafish as a model system – most notably their conservation to our human anatomy and physiology in regard to pigmentation, myelin formation, and visual function. In addition, we take advantage of the amazing capacity of the zebrafish to regenerate its entire retina following injury or disease. Click on one of the buttons below to find out more details about each project.
Specific projects in the lab fit into four distinct categories. The two main vision research projects of the lab focus on retinal development in a zebrafish model of genetic leukoencephalopathy and adult retinal regeneration in zebrafish. In addition, we collaborate with two other research teams on campus to explore related questions in pigment cell biology and adult stem cells. In collaboration with James Granneman, we use the zebrafish model to address the evolution and structure of pigment cells. And in collaboration with Jeffrey Taub and Tracie Baker, we have developed a zebrafish model of leukemia.